Kamsack Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Kamsack Presbytery, which had been part of the Presbyterian Synod of Saskatchewan.

In 1956, Kamsack Presbytery amalgamated with Abernethy-Yorkton Presbytery, becoming Yorkton Presbytery.

Kamsack Pastoral Charge was formed as a new United Church charge in 1925, containing Westminster United Church (Kamsack). Around 1965, the Togo preaching point was added and the charge was later re-named Kamsack-Togo Pastoral Charge. The preaching place at Togo closed June 30, 2005.

Cote Pastoral Charge was formed as a new United Church charge in 1925, as part of Kamsack Presbytery. It primarily consists of the Cote preaching place. In 1984, the charge joined the new Plains Presbytery, which became part of the All Native Circle Conference when it was formed, in 1989.