Ruddell Pastoral Charge was formed as a self-sustaining United Church charge in 1925, part of Battleford Presbytery and consisting of the preaching points at Denholm and Ruddell. By 1936, the Lilac appointment was added and, by 1940, the charge had been renamed Ruddell-Denholm Pastoral Charge. As of 1951, Wavie Bank was also listed as a preaching point. Sometime between 1951 and 1958, the charge was closed, with Ruddell joining Maymont Pastoral Charge and Denholm joining Battleford Pastoral Charge (as of 1962).

Grand Coulee Pastoral Charge was formed as a new United Church charge in 1925, as part of Regina Presbytery. Initially, the charge included preaching points at Grand Coulee and Sherwood. In 1948, the charge also added the Richardson preaching point. From 1968 until 1970, Grand Coulee was part of a six-point Pastoral Charge, with Pense, Drinkwater, Stoney Beach, Richardson and Sherwood. When this ended, Grand Coulee and Sherwood joined Wascana Pastoral Charge.

Around 1973, Grand Coulee re-established its own Pastoral Charge, and soon after these points joined with Pense, Drinkwater and Stoney Beach to form Pense - Grand Coulee Pastoral Charge. (Sherwood stayed in Wascana Pastoral Charge, eventually closing, June 30, 1990.) After the joint-charge was dissolved, Grand Coulee Pastoral Charge was re-established. In 1994, Grand Coulee and Pense-Drinkwater Pastoral Charges amalgamated, as Plainsview Pastoral Charge. The points at Pense and Drinkwater both formally closed on June 30, 1998, leaving Grand Coulee as the remaining congregation in the charge.

Prairie Spirit Pastoral Charge was formed March 1, 2006, from the amalgamation of Wiseton-Dinsmore Pastoral Charge and the Milden preaching point (previously part of Wheatlands Pastoral Charge).

Saskatoon Westminster Pastoral Charge was formed 1925, as part of Saskatoon Presbytery and consisting of Westminster United Church. Around 1968, Westminster United amalgamated with Grace United Church, to form Grace-Westminster United Church (and Pastoral Charge), in Saskatoon.

Shellbrook Pastoral Charge was formed as a United Church charge in 1925, part of Prince Albert Presbytery and consisting of Shellbrook, Hilldrop and Jack Pine appointments. As of 1932, the charge consisted of Shellbrook, Hilldrop, Cameo and Wild Rose. Rozilee and Briarlea also joined them, by 1936, as well as Holbein and Parcee, ca.1940. Between 1946 and 1951, Canwood, Polwarth and Marchant Grove (previously Canwood Pastoral Charge) moved to Shellbrook Pastoral Charge, alongside Cameo, Foxdale, and Shellbrook points. By 1962, the only remaining points listed were Shellbrook, Canwood and Marchant Grove (until ca.1967).

Around 1972, Canwood moved to Big River Pastoral Charge (soon after re-named Big River - Canwood Pastoral Charge) and Shellbrook joined with points at Craigmore and Leask to create Shellbrook-Leask Pastoral Charge. After 1975 or so, Craigmore is no longer listed in the charge (it may have closed). Leask closed October 29, 2005.

Marquis Pastoral Charge was formed as a self-sustaining United Church field in 1925, part of Moose Jaw Presbytery, with appointments at Marquis and Keeler. Between 1926 and 1932, the Marquis preaching point joined Tuxford Pastoral Charge (initially called Buffalo Lake Pastoral Charge) and Keeler was not listed within the Presbytery. By 1936, Keeler had joined with Lake Valley to form Keeler Pastoral Charge.

Between 1951 and 1958, Marquis Pastoral Charge re-formed. As of 1962, preaching points included Marquis, Keeler and Tuxford. Around 1970/71, Tuxford joined Moose Jaw Minto Pastoral Charge, alongside the Minto and Boharm appointments -- the points remained together until around 1974.

Rockglen Pastoral Charge was formed as a United Church charge sometime between 1926 and 1932, part of Assiniboia Presbytery and consisting of preaching points at Killdeer and Lacordaire (the latter was previously part of Pretty Valley Pastoral Charge, ca.1926). Between the late-1930s and 1940, the charge had amalgamated with Constance, as Rock Glen - Constance Pastoral Charge, with additional points at Lacordaire, Canopus and Killdeer (only Fife lake by 1946). By 1951, the charge had joined with Coronach to form Rock Glen - Coronach Pastoral Charge, with points at Rockglen, Coronach, Fife Lake, Hart and Clydesdale. The charges had separated again by 1958. As of 1962, Rockglen Pastoral Charge consisted of the Rockglen, Fife Lake and Killdeer congregations.

Around 1968/1969, Coronach combined with Rockglen Pastoral Charge (including Killdeer and Fife Lake) to create the new Borderlands Pastoral Charge.

The United Church of Canada was formed in 1925, from a union of the Congregational Union of Canada, the Methodist Church and 70% of the Presbyterian Church in Canada, along with a number of churches organized under the General Council of Local Union Churches (mostly in Western Canada). Saskatchewan Conference was one of eleven regional Conferences established by the United Church of Canada General Council, at their inaugural meeting, in June 1925. Initially, the Conference contained 16 presbyteries but this number varied, in the years that followed.

In January 2019, as part of a larger restructuring of the United Church of Canada, Saskatchewan Conference and its seven existing presbyteries were combined into a single entity, initially identified as Region 4 and later renamed Living Skies Regional Council.

Arcola-Estevan Presbytery was created from the amalgamation of Arcola Presbytery and Estevan Presbytery, in 1951. In 1973, Arcola-Estevan Presbytery was combined with part of Assiniboia Presbytery, becoming the new Souris Valley Presbytery.

Cypress Hills Presbytery was created, in 1959, from the merger of Swift Current Presbytery and the part of Assiniboia Presbytery west of Highway 19.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Cypress Hills Presbytery became part of the new Chinook Presbytery.

Qu’Appelle Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Qu’Appelle Presbytery, which had been part of the Presbyterian Synod of Saskatchewan.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Qu’Appelle Presbytery became part of the new Twin Valleys Presbytery.

Saskatoon Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Saskatoon Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Saskatchewan District, in the Saskatchewan Conference of the Methodist Church.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Saskatoon Presbytery became part of the new River Bend Presbytery.

Good Spirit Presbytery was one of the 7 presbyteries of Saskatchewan Conference created in 2000. It was initially comprised of pastoral charges formerly part of Parkland Presbytery (previously Yorkton Presbytery). In January 2019, as part of a larger restructuring of the United Church of Canada, Good Spirit Presbytery was combined with Saskatchewan Conference and the other remaining presbyteries to become Region 4.